The United States and China had the highest diabetes-related health expenditures in 2021, totaling $380B and $165B, respectively. This can be attributed to the high number of people with diabetes in these countries. China had 141 million people with diabetes in 2021, the highest number globally, and is forecasted to increase to 174M by 2045. The United States had the fourth-highest number of adults with diabetes in 2021, with a total of 32.2 million. The high prevalence of diabetes, the cost of diabetes medications and treatment, and the overall high healthcare costs in the US contribute to this expenditure.